SIRFLOX clinical trial Selective Internal Radiation Therapy SIR-Spheres treatment liver metastases liver tumour colorectal cancer

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Selective Internal Radiation Therapy using SIR-Spheres

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Sponsor and SIR-Spheres Y-90 resin microspheres

Sirtex Medical Limited

The SIRFLOX study is sponsored by Sirtex Technology Pty Ltd., a wholly owned subsidiary of Sirtex Medical Limited (Sirtex). Headquartered in Sydney, Australia, Sirtex is a public company listed on the Australian Securities Exchange (ASX: SRX). The primary objective of Sirtex is to research, develop, and commercialise effective treatments for liver cancer using novel small particle technology.

About SIR-Spheres Y-90 resin microspheres

Microspheres SIR-Spheres Y-90 resin microspheres are biocompatible polymer microspheres containing yttrium-90 with a size between 20 and 60 microns in diameter. A high-energy beta-emitting isotope, Yttrium-90 has a half-life of 64.1 hours. The maximum range of emissions in tissue is 11mm with a mean of 2.5mm. In therapeutic use, requiring the isotope to decay to infinity, 94% of the radiation is delivered in 11 days. SIR-Spheres Y-90 resin microspheres distribute non-uniformly in the liver due to the physiology of hepatic arterial flow, the tumour to normal liver ratio of the tissue vascularity and tumour size. The rim of the tumour gets higher density per unit distribution of SIR-Spheres Y-90 resin microspheres than the normal liver. SIR-Spheres Y-90 resin microspheres are a sealed-source device.

For more information on SIR-Spheres Y-90 resin microspheres, please see "About SIR-Spheres" on www.sirtex.com

Click on the the links below for SIR-Spheres Y-90 resin microspheres package insert:

USA (pdf, 239 kB)
Non USA (pdf, 240 kB)

W005-EUA-0315 

About the SIRFLOX study

The SIRFLOX study is an international research study designed to evaluate a new treatment option for patients with colorectal cancer that has undergone metastatic spread to the liver.

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SIRFLOX clinical trial Selective Internal Radiation Therapy SIR-Spheres treatment liver metastases liver tumour colorectal cancer